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・ Gaius Claudius Severus
・ Gaius Cluilius
・ Gaius Cocceius Balbus
・ Gaius Coelius Caldus
・ Gaius Considius Longus
・ Gaius Cornelius Cethegus
・ Gaius Crastinus
・ Gaius Dillius Vocula
・ Gaius Domitius Dexter
・ Gaius Doumde
・ Gaius Duilius
・ Gaius Epidius Marullus
・ Gaius Fabius Ambustus
・ Gaius Fabius Ambustus (magister equitum 315 BC)
・ Gaius Fabius Hadrianus
GAIT element
・ Gait trainer
・ Gait training
・ Gaita
・ Gaita asturiana
・ Gaita cabreiresa
・ Gaita de boto
・ Gaita de saco
・ Gaita gastoreña
・ Gaita Mainda
・ Gaita navarra
・ Gaita sanabresa
・ Gaita transmontana
・ Gaita zuliana
・ Gaita-de-fole Coimbrã


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GAIT element : ウィキペディア英語版
GAIT element

The gamma interferon inhibitor of translation element or GAIT element is a cis-acting RNA element located in the 3'-UTR of the ceruloplasmin (Cp) mRNA.
The GAIT element forms a stem-loop secondary structure. The GAIT element is involved in selective translational silencing of the Cp transcript. Cp is a multifunctional, copper-containing glycoprotein produced by the liver and secreted into the plasma. As an acute-phase protein, its plasma concentration can double during multiple inflammatory conditions. Plasma Cp has been reported to be an independent risk factor for cardiovascular disease, including atherosclerosis, carotid restenosis after endarterectomy, and myocardial infarction. Translational silencing of Cp, and possibly other transcripts, mediated by the GAIT element may contribute to the resolution of the local inflammatory response following cytokine activation of macrophages.
The silencing of Cp requires binding of the IFN-gamma-activated inhibitor of translation (GAIT) inhibitor complex to the GAIT element. The GAIT complex consists of the proteins ribosomal protein L13a, glutamyl-prolyl-tRNA synthetase, NS1-associated protein-1, and glyceraldehyde 3-phosphate dehydrogenase.
==References==



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